Nasal Spray developed to treat traumatic brain injury

A new study led by researchers at Mass General Brigham said a nasal spray developed to target neuroinflammation that could be an effective treatment for traumatic brain injury (TBI).

A mouse model of TBI, researchers found the spray could reduce damage to the central nervous system and behavioral deficits, suggesting a potential therapeutic approach for TBI and other acute forms of brain injury. The results are published in Nature Neuroscience.

“Traumatic brain injury is a leading cause of death and disability — including cognitive decline — and chronic inflammation is one of the key reasons,” said lead author Saef Izzy, MD, FNCS, FAAN, a neurologist and head of the Immunology of Brain Injury Program at Brigham and Women’s Hospital.

Currently, there is no treatment to prevent the long-term effects of traumatic brain injury.

The team examines the monoclonal antibody Foralumab, made by Tiziana, which has been tested in clinical trials for patients with multiple sclerosis, Alzheimer’s disease, and other conditions.

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